The Gene Formula
COMT SNP & Female Wellbeing Guide
COMT SNP & Female Wellbeing Guide
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A practical, 90-page guide to understanding your unique COMT gene type — whether slow, fast, or intermediate — and how it may influence your mood, hormone balance, energy, and stress response. This isn’t a science-heavy PDF. It’s a clear, body-led resource designed to help you feel more balanced, focused, and resilient — without complicated protocols.
You’ll explore how COMT impacts key areas of women’s health, including estrogen metabolism, nutrition and supplements, detox and longevity, sleep and recovery, mood regulation, and movement. Each chapter offers specific insights for all three COMT types, so you can quickly find what’s most relevant for you.
At the end, you’ll find a simple 7-day COMT Action Plan tailored to each type, helping you start with confidence and begin feeling real shifts in your daily life. This guide is about working with your chemistry, so you can feel more clear, energized, and in tune with yourself, every single day.
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WHATS INSIDE THE E-BOOK?
Nutrition & Supplementation
In this chapter:
We’ll explore simple, practical nutrition strategies and supplements tailored to each of the three COMT types — to help you feel more nourished, balanced, and in sync with your body.
Biological Insight:
COMT helps break down dopamine, adrenaline and estrogen, which influence cravings, mood, and digestion. Nutrition plays a key role here, especially for fast COMT types who burn through neurotransmitters quickly.
How You Might Feel:
Slow COMT types may feel bloated or sensitive during stress or high-estrogen phases. Fast COMT types often need regular nutrient support to stay motivated and grounded. Intermediate types may notice gut shifts depending on stress or cycle phase.
Longevity & Detox
In this chapter:
You’ll find simple, COMT-specific strategies to support your detox pathways with a focus on longevity and energy that builds over time.
Biological Insight:
COMT helps clear stress chemicals and estrogen byproducts — but it also plays a surprising role in your body’s ability to process toxins like heavy metals. When this pathway is slowed or overactive, it can affect how well your cells recover, detox, and age.
How You Might Feel:
Slow COMT types may for example feel more weighed down by pollutants, inflammation, or mental fatigue, especially if antioxidant support is missing. Fast COMT types may deplete detox nutrients faster and need steady replenishment.
Sleep & Recovery
What You’ll Get:
Gentle, type-specific strategies to support better rest, deeper recovery, and more resilient mornings.
Biological Insight:
COMT influences how quickly your brain clears dopamine and adrenaline — which plays a key role in sleep onset, depth, and nighttime overthinking.
How You Might Feel:
Slow COMT types may struggle with falling or staying asleep. Fast COMT types often wake unrefreshed. Intermediate types tend to be more cycle-sensitive.
Mood Regulation
What You’ll Get:
Tools to support your emotional regulation style with practices that honor sensitivity, and deepen your connection to self.
Biological Insight:
COMT influences how your body clears mood-related neurotransmitters like dopamine and norepinephrine — which can shape how emotions rise, settle, and linger.
How You Might Feel:
If your clearance is slower, you might feel more deeply and might take longer to shift states. Faster metabolizers may move on quickly but sometimes miss emotional highs.
Movement & Lifestyle
What You’ll Get:
Nervous-system-friendly and COMT specific movement strategies to support energy, mood, and long-term balance.
Biological Insight:
COMT influences how you metabolize stimulation (like neurotransmitters), shaping your response to physical stress (workouts), energy levels, and recovery needs.
How You Might Feel:
Slow types may feel wired or tense after too much intensity. Fast types can burn out without enough recovery. Intermediate types shift with hormones and stress and need freedom for more adaption.
Estrogen Metabolism
What You’ll Get:
Helpful strategies to support estrogen metabolism matched to your COMT type.
Biological Insight:
COMT helps break down estrogen byproducts. When this is slowed or sped up, it can shift your hormonal balance. Very interesting section esp. for women who have their hormonal DUTCH test results by hand.
How You Might Feel:
Slow COMT may lead easier to PMS or estrogen buildup. Fast COMT may clear estrogen too quickly, causing low-estrogen signs. Intermediates can shift based on stress or liver health.
Understand Your Chemistry. Change Your Experience.
COMT is one of the high impactful genetic variations (SNPs) for women, influencing how your body processes dopamine, adrenaline, and estrogen — three key messengers that shape your mood, focus, stress response, and hormonal balance.
Its effects can be especially noticeable during hormonally intense or high-demand phases of life. There are three common COMT types, each with its own processing rhythm. Understanding your variation can offer powerful insight into how your system responds and how to support it with more precision and care.
Ever wondered if...
... your PMS symptoms feel more intense than others seem to experience? (Slow COMT)
... you need constant stimulation to feel motivated? (Fast Comt)
... stress hits harder during certain parts of your cycle? (Intermediate COMT)
The 3 "Messengers" COMT Helps Regulate and Why They Matter:
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Estrogen
COMT helps break down estrogen byproducts, which is especially important for women during hormonal highs like ovulation or PMS. If this process is slow, it can contribute to mood swings, bloating, fatigue, or even estrogen dominance symptoms.
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Dopamine
Dopamine supports focus, motivation, and emotional engagement. Depending on your COMT type, this signal may linger or fade quickly, influencing how easily you concentrate, how inspired you feel, and whether your mind tends to spark with ideas or slip into mental fatigue.
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Adrenaline (Epinephrine)
This stress hormone helps you react quickly, but how long it stays active depends on your COMT type. Slow COMT clears it slowly, you may feel wired after stress. If it clears too fast, you might feel underpowered or crash easily. Your COMT rhythm shapes how quickly you return to calm after pressure or conflict.
Who Is This For?
You’re done blaming yourself for low focus and ready to work with your dopamine rhythm.
You’re ready to ease the weight of high estrogen - with clarity, and self compassion.
You’re learning to read your body’s signals before they speak in symptoms.
Why now?
Because the longer you guess, the more time, money, and energy you waste on solutions that weren’t made for you.
Now is the moment to get clear and reconnect with your biology. This is your invitation.
FAQs - The most-asked, all in one place.
Do I need to test my COMT before buying the guide?
Not necessarily — though having your results can offer helpful clarity. The guide includes a clear overview of traits linked to all three COMT types, so you may already recognize yourself in one of them. We also share two easy testing options if you’d like to confirm your type later on.
Who is this guide for?
This guide is for women who want to better understand how their unique neurochemistry shapes their mood, energy, stress resilience, and hormonal balance.
Personally, learning about my own COMT SNP was a turning point in my journey with hormonal imbalance, especially with excess estrogen. Depending on your genetic predisposition and real-life epigenetic influences, COMT can become a metabolic bottleneck for estrogen. Knowing this helped me make both short-term adjustments and build long-term strategies that actually worked with my biology — not against it. This guide is meant to offer the same clarity and empowerment to you.
You only need to do it once and it can inform every health decision you make moving forward.
Is this guide still helpful if I’m already working with a practitioner?
Yes, absolutely. Many practitioners appreciate when clients come in with a clearer understanding of their genetics, because it allows for even more personalized and effective care.
This guide can complement your work together by helping you understand how your COMT type might influence your mood, hormones, and stress resilience and by giving you practical tools and language to ask more targeted, informed questions.
No two bodies are the same, and this guide helps you tune in to yours.
Does this eBook or my COMT variant diagnose any conditions or tell me something bad?
No. This guide is not a diagnostic tool and your COMT variant is not a sentence — it’s simply one piece of insight into how your body might process stress, hormones, and certain neurotransmitters.
COMT doesn’t predict disease. It helps you understand patterns, like why you might feel wired after coffee, emotionally intense during parts of your cycle, or more sensitive to pressure than others.
The goal of this guide isn’t to label you, but to empower you. With practical tools, type-specific suggestions, and body-led support, it’s here to help you feel more resourced, not restricted.
I’ve already tried a lot. How is this different?
Most wellness advice assumes we all respond the same way, but your body’s chemistry has its own rhythm. This guide goes beyond surface-level protocols and helps you understand why something may or may not have worked for you in the past. By exploring how your COMT type affects dopamine, adrenaline, and estrogen metabolism, you’ll learn what kind of support your system truly needs not just based on symptoms, but on how you're wired.
It’s not about overhauling your life. It’s about tuning into your natural rhythm and choosing strategies that actually match how your body operates, so changes feel doable, not draining.
Of course, COMT is just one gene, but it's a high-impact one, especially for women. Starting here can offer clarity and momentum, even as you explore the broader genomic picture.
This is where your body awareness becomes change.
You’ve sensed there’s more to your mood, your energy, your cycle and you’re right. This guide gives you practical, personalized insight into your COMT type, so you can stop second-guessing your body and start supporting it.
No overwhelm. No fluff. Just real tools, for real women, ready to feel more clear, balanced, and in charge. Download your pdf guide and begin the shift today.
The Gene Formula
COMT SNP & Female Wellbeing Guide
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